![]() ![]() Why are we measuring the BUN/Creatinine ratio? When results of a creatinine test reveal excess amounts, it could signify impaired kidney function or kidney disease. Because muscle mass remains fairly consistent, creatinine levels remain essentially unchanged throughout the day. The rate of creatinine formation depends on the individual’s muscle mass. Like urea, creatinine is transported through the bloodstream and to the kidneys, where it is also filtered and excreted through the urine. It is normal to have some urea present in the blood since your liver is always producing it, but too much may indicate an issue with your kidneys.Ĭreatinine is another type of molecule that is generated from muscle metabolism. Healthy kidneys then filter the urea and remove other waste products like urea through urination. The nitrogen comes from the waste product urea, which is converted from nitrogen and produced in the liver when protein is metabolized after eating. ![]() Note: If results for BUN and Creatinine are both within the normal reference range, the BUN/Creatinine ratio will not be reported (not applicable).Ī Blood Urea Nitrogen (BUN) test measures the amount of nitrogen in your blood, and is used to provide doctors with information on how well your kidneys and liver are functioning. However, the BUN to creatinine ratio may be used as an indirect estimate of renal function. Most clinicians agree that creatinine is a more specific indicator of glomerular function than BUN. The BUN and creatinine tests alone are excellent methods of testing liver and kidney health, but together, doctors get a much better understanding of your kidney health and can provide a more accurate diagnosis to kidney-related issues. Once a person performs both a BUN and Creatinine test, doctors can use the combined results to find the BUN-to-creatinine ratio. doi:10.3121/ Blood urea nitrogen (BUN): Creatinine Ratio is a renal (related to kidneys) function indicator, commonly used to diagnose acute or chronic renal (kidney) disease or damage.īlood Urea Nitrogen (BUN) and creatinine are both waste products of normal metabolism in the human body.īUN represents the amount of nitrogen produced from the metabolism of proteins.Ĭreatinine is a normal waste product of muscle. Biochemical testing of the thyroid: TSH is the best and, oftentimes, only test needed - A review for primary care. The association between subclinical hypothyroidism and sleep quality: A population-based study. Effect of high-dose biotin on thyroid function tests: Case report and literature review. Reviewed May 2017.Īrdabilygazir A, Afshariyamchlou S, Mir D, Sachmechi I. ![]() National Institute of Diabetes and Digestive and Kidney Diseases. Does fasting or postprandial state affect thyroid function testing? Indian J Endocrinol Metab. Nair R, Mahadevan S, Muralidharan RS, Madhavan S. Interferences with thyroid function immunoassays: Clinical implications and detection algorithm. Pitfalls in the measurement and interpretation of thyroid function tests. Koulouri O, Moran C, Halsall D, Chatterjee K, Gurnell M. ![]() 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Comorbidities, concomitant medications, and diet as factors affecting levothyroxine therapy: results of the CONTROL Surveillance Project. Thyroid and pregnancy: Thyroid status and risk of miscarriage.Ĭhaker L. Evaluation of pregnancy and thyroid function. Gender-specific regulation of response to thyroid hormone in aging. Suzuki S, Nishio SI, Takeda T, Komatsu M. Normal TSH reference range: What has changed in the last decade? JCEM. Seasonal variations in levels of human thyroid-stimulating hormone and thyroid hormones: a meta-analysis. Kuzmenko NV, Tsyrlin VA, Pliss MG, Galagudza MM. TSH reference ranges should be used to safely guide thyroid hormone treatment in hypothyroid patients. ![]()
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